ea0077p63 | Metabolism, Obesity and Diabetes | SFEBES2021
Pieri Kyriaki
, Trichia Eirini
, Neville Matt J
, Taylor Hannah
, Bennett Derrick
, Karpe Fredrik
, Koivula Robert W
Background: Type III hyperlipidaemia (T3HL) is characterised by equimolar increases in plasma triglyceride and cholesterol on an APOE2/2 genotype background and conveys a high risk of early-onset cardiovascular disease (CVD). Phenotypic penetrance of T3HL is <10% and precipitated by several endocrine/metabolic disorders such as obesity, diabetes and hypothyroidism. We explored the effect of triglyceride-raising polygenic score precipitating T3HL, in the context of...